Utilizing knowledge gained from almost 40 years of experience in the field, Charles River offers a full range of inhalation toxicology study designs to support the worldwide registration of agrochemical products. Our modern laboratory facilities and custom-designed apparatus provide the capability to conduct a variety of study designs in multiple species.

Study Types

• Acute toxicity
• Subacute to chronic
• Reproduction and teratogenicity
• Neurotoxicology
• ADME/ TK

• Dry powders
• Aerosols
• Emulsion sprays
• Vapors
• Gases

Analytical Support

Analytical methodologies specific to the compound under investigation are developed and validated using appropriate equipment and systems [e.g., Gas Chromatography (GC), High-Performance Liquid Chromatography (HPLC) and Ultra-Performance Liquid Chromatography (UPLC)]. Test atmospheres are routinely sampled using sorbent tubes or impingers and assessed gravimetrically or chemically.

Online infrared or GC analysis is routinely used for gases and vapors and Real-time Aerosol Monitors (RAM) are available for measuring particulates.

Aerosol particle size distribution is monitored using a variety of Cascade Impactors (with subsequent chemical analysis if required) or a laser optical system (API Aerosizer^®, TSI Inc.).

For more information about our inhalation toxicology studies, contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.