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physicochemical characterization, analytical chemistry & stability testing
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Physicochemical testing is an integral requirement of product registration for biocides. Charles River has vast experience conducting various physicochemical testing packages (or stand-alone tests) to assess the environmental impact and safety of an active ingredient and its formulated products. We offer a full range of physicochemical testing to meet all regulatory requirements, such as OECD, CIPAC, OPPTS and OJEC. These include, but are not limited to;
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Physical state
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Melting point
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Boiling point
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Relative density
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Surface tension
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Water solubility
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Organic solvent solubility
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Octanol/water partition coefficient
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Dissociation constant
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Flammability
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pH
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Viscosity
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Oxidizing or reducing properties
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Rate of hydrolysis (cold)
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Spectra (UV, UV/VIS, IR, NMR, MS)
Our Product Chemistry group offers all the characterization and physicochemical studies (active ingredients and formulated products) necessary to support registration worldwide.
We provide the technical and analytical support required for toxicity, ecotoxicity and environmental fate studies. All quantitative analytical procedures are subject to rigorous validation before use. When no analytical procedures exist, we can undertake full method development.
Analytical Capabilities
A suitable validated analytical method is required to support many product chemistry and ecotoxicology tests. Experienced analysts are available to establish new analytical methods or to transfer existing methodology using a wide range of up-to-date equipment:
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HPLC (UV/visible, diode array, fluorescence, refractive index, light scattering, electrochemical)
- GC (FID, TCD, ECD, FPD)
- LC-MS, GC-MSD, LC-MS/MS, time of flight (QToF, IT-ToF)
- Capillary electrophoresis (diode array, UV/visible)
- Dionex ion chromatography (conductivity detection)
- IEP-OES (Optima 8000)
Stability Testing
The storage stability and shelf-life of the formulated product can also be determined under a variety of specified storage conditions. Solid, liquid, semi-solid and aerosol formulations can all be evaluated using real-time and accelerated storage stability testing. We have dedicated facilities to stress the material using monitored heat, humidity or light parameters.
For more information about our physicochemical characterization, analytical chemistry and stability testing services, contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.
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Physicochemical, Physicochemical characterization, analytical chemistry, stability testing, Physical state, Melting point, Boiling point, Relative density, Surface tension, Water solubility, solubility, Octanol, water, partition coefficient, Dissociation constant, Flammability, pH, Viscosity, Oxidizing, reducing, hydrolysis, agrochemical, HPLC, diode array, GC, FID, NPD, TCD, ECD, FPD, LC-MS, GC-MSD, LC-MS/MS, time of flight, QToF, IT-ToF, Capillary electrophoresis, Dionex ion chromatography
Physicochemical Characterization & Analytical Chemistry | Biocide Development | Charles River
Charles River has vast experience conducting various physicochemical testing packages (or stand-alone tests) to assess the environmental impact and safety of an active ingredient and its formulated products.
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For more information, contact us at: 1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com
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