human virus antigens & antisera 

We know you need expert support that can manufacture, process and validate reagents to give you access to clean, specific, high-potency preparations. Charles River Avian Vaccine Services offers human influenza type A and B viruses supplied as allantoic fluid, concentrates and gradient-purified, as well as Sendai virus (Cantell Strain) supplied as sterile allantoic fluid. We can also provide outsourcing of virus preparations with customer-supplied Biosafety Level 1 and 2 viruses to researchers in a variety of disciplines. Viruses are grown in specific pathogen-free (SPF) embryonated eggs and they can be produced in large or small quantities to meet your needs. The final preparations can be delivered in crude (bulk fluids), concentrated, fractioned or purified forms, depending upon your specific requirements.

Influenza Types

• Influenza A/PR/8/34 (H1N1)
• Influenza A X-31, A/Aichi/68 (H3N2)
• Influenza A/Victoria/3/75 (H3N2)
• Influenza A/Hong Kong/8/68 (H3N2)
• Influenza B/Lee/40
• Customer Supplied Virus

Sendai Virus

The original virus was obtained from American Type Culture Collection (ATCC), product code VR-907, identified as Parainfluenza 1, Sendai/Cantell strain. It was passaged several times by inoculating the virus into the Chorioallantoic Sac of 9- to 11-day-old embryonated SPF chicken eggs. Virus is supplied as sterile, clarified Allantoic fluid at a minimum titer of 2000 HA units/mL, or purified to 2 mg/mL.

Antiserum Production

Antiserum was produced in SPF chickens. The chickens were removed from an existing SPF flock and brought to the laboratory animal facility where they were housed in a single room under strict biosecurity and HEPA-filtered air under positive pressure. Liquid and lyophilized avian antisera for Influenza A/PR/8/34 and Sendai (Cantell Strain) are available in 1 mL, 5 mL, 10 mL, 50 mL, and 100 mL vials.

See our complete list of Avian Laboratory Products and Services.