cell and virus seed bank storage 

In conjunction with our cell banking and vaccine production services, Charles River Biopharmaceutical Services (BPS) can help you ensure both the safety and security of your cell and virus seed banks. BPS provides long-term storage of client banks according to current Good Manufacturing Practice (cGMP) in a highly controlled, secure and monitored environment. With more than ten years of experience, BPS has developed processes to minimize the risks associated with cell bank storage, without hampering client accessibility.

Security, Continuous Monitoring, Compliance

To minimize the risk of a freezer malfunction, each client bank is divided and stored in separate cGMP liquid nitrogen freezers (less than -150^◦C) or -70°C freezers, as appropriate. The liquid nitrogen levels and freezer temperatures are under a continuous 24-hour monitoring system. The security of the storage facility and the client’s valuable resources are ensured by a fully redundant backup system.

Regulatory Compliance

BPS strictly abides by global regulatory guidelines to ensure that all facilities, practices and procedures are in compliance. All cell and virus seed banks are manufactured and stored in compliance with both the US Food and Drug Administration (FDA) and International Conference of Harmonisation (ICH) guidelines.

Cell and Virus Seed Bank Storage Features

Material Storage

• Materials stored in a cGMP facility in accordance with sponsor-defined conditions
• Short- and long-term storage in vapor-phase liquid nitrogen or at -70°C, as appropriate
• Segregation to minimize cross-contamination
• Dedicated dewars for mammalian, microbial and insect cell banks
• Inventory control system

 

Sample Monitoring and Security

• Temperature-mapped storage units maintained in a limited-access and controlled suite
• 24-hour validated redundancy temperature monitoring system
• Auxilliary backup generators routinely tested

 

Shipment

• Stored material shipped as needed by client specifications
• Shipment of cell banks in multiple shippers for safety
• Temperature monitors
• Any destination worldwide
• Technicians certified in dangerous goods shipping under US Department of Transportation and International Air Transport Association guidelines

To check which of our BPS facilities offer cell and virus seed bank storage, click here. For more information, contact us at askcharlesriver@crl.com or 1.877.CRIVER.1.