Inflammation Models | Charles River Discovery Research Services

Delayed-Type Hypersensitivity (DTH) Model 

In our delayed-type hypersensitivity (DTH) model, we use oxazolone to stimulate a DTH response. Five days post-sensitization, a delayed-type hypersensitivity response is elicited in the animals by painting the inner and outer surfaces of the right ear with oxazolone, while the left ear is painted with vehicle. Subsequent treatment is administered and the animal's ears are measured at 24, 48 and 72 hours post-elicitation. Because the inflammation reaction involves the rapid recruitment of macrophages and basophils and then T-cells within 48 hours, this study can be a rapid screening for anti-inflammatory compounds.


Data

Chart of Ear Swelling in Delayed-Type Hypersensitivity (DTH) Mouse Model (Cutaneous Sensitization)

Ear Swelling in DTH Mouse Model (Cutaneous Sensitization)  

 

 

 

Ear Swelling in a Model of DTH

 

Ear Swelling in a Model of DTH 

 

 

 

Total Disease Burden in DTH

 

                 Total Disease Burden in DTH 

 

 

 

 

 

For more information about our Delayed-Type Hypersensitivity (DTH) model, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.

Discover the full range of Charles River Products and Services
The Source

For more information, contact us at:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

view all

News & Events

view all
May 13 - High-Throughput Screening for CNS ...
May 08 - Comparability Studies for Monoclon...
May 28-Jun 01 - Kobe, Japan - Joint Meeting of the International Bone and Mineral Socie...
May 23-May 23 - East Lansing, Michigan, USA - The Ins and Outs of Transgenic Colongy Ma...

Charles River Laboratories, Inc.