Diabetic Research Models | Type 1 and Type 2 | Charles River

ob/ob model 

The ob/ob mouse is a monogenic model of obesity induced diabetes.  ob/ob mice are deficient in the hormone leptin.  This protein is expressed predominantly in adipose tissue of normal mice.  Leptin plays a major role in regulating body energy efficiency and satiety.  While leptin deficiency in humans is exceedingly rare, ob/ob mice exhibit many of the metabolic abnormalities of diabetes.  This includes insulin resistance, hyperinsulinemia, non-fasting hyperglycemia, impaired glucose tolerance, and adipose tissue abnormalities. 

Effects of Standard Agents on Non-Fasted Blood Glucosed in ob/ob Mice

Effect of Standard Agents on Non-Fasting Blood Glucose in ob-ob Mice

 

 

Effect of Standard Agents on OGTT in ob-ob Mice


Effect of Standard Agents on OGTT in ob-ob Mice

 

Effects of Standard Agents on Plasma Triglycerides in ob/ob Mice

Effect of Standard Agents on Plasma Triglycerides in ob-ob Mice

 

 

   

Effects of Standard Agents on Plasma Insulin in ob-ob Mice

Effects of Standard Agents on Plasma Insulin in ob-ob Mice 

 

 

  

For more information about our diabetes research studies with the ob/ob model, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.

Discover the full range of Charles River Products and Services
The Source

For more information, contact us at:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

view all

News & Events

view all
Jun 13 - Neurological Biomarkers in Efficac...
Jun 06 - GLP-Compliant ELISpot and FluoroSp...
Jun 24-Jun 26 - London, UK - Skin Forum 2013
Jun 21-Jun 25 - Chicago, IL - American Diabetes Association’s 73rd Scientific Sessions
Sep 09-Sep 11 - Carlsbad, CA - 19th Annual Biotechnology-Derived Therapeutics Perspecti...
Jun 28-Jun 28 - Frankfurt, Germany - Seminar: Health Monitoring of Laboratory Animals

Charles River Laboratories, Inc.