The ob/ob mouse is a monogenic model of obesity induced diabetes. ob/ob mice are deficient in the hormone leptin. This protein is expressed predominantly in adipose tissue of normal mice. Leptin plays a major role in regulating body energy efficiency and satiety. While leptin deficiency in humans is exceedingly rare, ob/ob mice exhibit many of the metabolic abnormalities of diabetes. This includes insulin resistance, hyperinsulinemia, non-fasting hyperglycemia, impaired glucose tolerance, and adipose tissue abnormalities.
Effect of Standard Agents on Non-Fasting Blood Glucose in ob-ob Mice
Effect of Standard Agents on OGTT in ob-ob Mice
Effect of Standard Agents on Plasma Triglycerides in ob-ob Mice
Effects of Standard Agents on Plasma Insulin in ob-ob Mice
For more information about our diabetes research studies with the ob/ob model, please contact us at 1.877.CRIVER.1 or email@example.com.