Charles River offers a comprehensive and integrated service for the isolation, analysis and identification of metabolites from biological matrices in support of compound safety and metabolism studies.
Our biotransformation chemists have many years of experience in the following areas:
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Chromatography method development
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Sample preparation method development
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Extraction of bound residues
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Radio-chromatographic profiling
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Isolation and purification of metabolites
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Metabolite identification using LC-MS/MS, QToF and IT-ToF for accurate mass and access to NMR
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Expert report preparation
Where additional confirmation of structures is desirable, we offer a synthetic chemistry service for providing putative metabolite reference standards. We also offer a rapid turnaround service for the repurification of impure test items.
Radiosynthesis
Charles River can assist with the procurement of radiolabeled molecules on behalf of clients. On request, we will be pleased to obtain estimates from specialist synthesis laboratories and will monitor progress through to delivery to our site. This service is totally confidential and free of charge, and does not commit the clients to using either Charles River or any of the laboratories involved. Additionally, we have chemists on-site who are experienced in the handling and repurification of radiolabelled molecules should that service be required. This allows us to preserve study timelines when radiolabelled molecules are unstable or impure.
Related Information
Webinar Replay - Early-Stage Metabolite Identification: Preparing for Clinical Development (December 2009)
For more information about our metabolite profiling and identification services, contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.