Aged Rats and Mice for Cognitive Decline Research 

Aged rat and mouse models are based on animals bred at Charles River. These animals begin to exhibit cognitive, biochemical and brain metabolism deficits at approximately 20 months of age. These models can be used to assess efficacy in age-related cognitive decline associated with Alzheimer’s disease and other diseases linked with aging. Aged rat and mouse studies can also be combined with scopolamine-induced amnesia. Aged cohorts of animals are available immediately for studies.

Models of Aging and Cognitive Decline

• Aged Rats
• Aged Mice
• Aged Rats with Scopolamine-Induced Amnesia
• Aged Mice with Scopolamine-Induced Amnesia

Example Study Paradigm of Rat and Mouse Models of Aging and Cognitive Decline

Click here to see a diagram outlining an example study paradigm using our aged rat and mouse models of cognitive decline.

Study Components

• Body weight
• Morris Water Maze (MWM) for learning and memory
• In vivo 1H-MR Spectroscopy for hippocampal metabolic profile
• Synaptophysin qPCR for synaptic marker

Additional End Point Options

• Synaptic
• qPCR for PSD95
• Synaptophysin IHC/WB
• Bioenergetic, Mitochondrial and Redox
• In vitro 31P-MRS for ATP, ADP, PCR, Pi
• In vitro 1H-MRS for PCR, CR, NAA, TAU, GLU, GLN, LAC, GABA, mINS, ACE, CHO and GSH
• Neurochemical
• HPLC for ACh, DA, 5HT, NE
• Cell Population and Proliferation
• Immunohistochemistry for NeuN, GFAP, and Iba-1
• BrdU
• Inflammatory and Oxidative Stress
• TNF-alpha, IL-1beta, Cyt C Oxidase, 3-NT, MDA, Isoprostane