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Biomedical manufacturers and conservationists alike have a vested interest in making sure the Atlantic horseshoe crab, whose ancestry dates back some 440 million years, flourishes.
Tiered approaches have been used in method validation for decades, but to what level CROs are using them in the preclinical arena—particularly early discovery—is difficult to say.
My top priority is the horseshoe crab, a sea creature of little interest in culinary circles but uniquely valuable to biomedical research.
The up and coming strategy called CiPA will allow us to know more about the potential liabilities of test articles before the start of a large animal telemetry study, but in practice, such information will have little impact on the design and conduct of in vivo safety pharmacology studies. Here's why.
Stem-cell derived human cardiomyocytes are commercially available in sufficient enough quantities to be practical for routine safety pharmacology studies.
Minipigs have been used extensively in dermal studies but the diminutive swine's role in animal research is expanding.
Biomarkers are ubiquitous in research and increasingly more sophisticated. Their promise and challenges were on full display this week at SOT2015.
The reciprocal relationship between bones and the immune system is reshaping how we view the role of the muskuloskeletal system.
The latest innovations and trends and over 2,500 abstracts will be highlighted at the Society of Toxicology's 54th Annual Meeting and ToxExpo in San Diego March 22-26.
Using more efficient data gathering software can maximize high-res mass spectrometry. The last in our three part series.