Featured Stories

State-of-the-Art Bioactivity Testing for Bevacizumab

11/05/2014

In addition to the traditional in vitro neutralization assays based on primary HUVEC endothelial cells, Charles River now offers the more cost-effective, robust and validatable VEGF reporter assay to illustrate the in vivo mechanism of action of bevacizumab and its follow-on biologics during the early phase of drug development. 

Rapid Bioactivity Testing for Parathyroid Hormone

11/04/2014

For historical reasons, parathyroid hormone (PTH) bioactivity is mainly determined by tedious and time-consuming cAMP ELISA assays. The newly established homogenous time-resolved fluorescence (HTRF) cAMP assay is an attractive alternative, enabling researchers to receive reliable PTH bioactivity data with improved assay robustness and validatability.

Acquisition Enhances Ion Channel Discovery Services

10/29/2014

Charles River has acquired ChanTest, a market leader in ion channel drug discovery and associated in vitro safety testing. The addition of this world-class organization to our Discovery Services portfolio complements our existing ion channel capabilities and broadens our scientific depth and the services we can provide to our clients in their mission to discover and develop new medicines.

ADCP: The Neglected Mechanism of Action

10/23/2014

In vitro antibody-dependent cellular phagocytosis (ADCP) assays based on primary macrophages as effector cells are excellent tools to illustrate the in vivo mechanism of action (MOA) of a therapeutic monoclonal antibody (mAb) during the early phase of drug development.

Clinical Sample Analysis for Biosimilars

10/21/2014

Charles River offers an integrated approach for the development of biosimilars, including regulatory consultation, testing and characterization, nonclinical studies and clinical sample analysis.

Multiplexing - Get More Value from Your Samples

10/16/2014

Multiplex assays offer several advantages that make them a sought after technology to increase efficiency in the lab and get the most information out of each sample taken. Charles River has validated several biomarker multiplexed assays and is in the process of qualifying and validating more.

Minipig Strains and the Emergence of the Göttingen Minipig

10/09/2014

ICH guidelines require the use of two species in nonclinical studies for pharmaceuticals; one rodent and one nonrodent species. With many anatomical, physiological and functional similarities to humans, the miniature pig (minipig, Sus scrofa) has become a viable alternative nonrodent animal model in nonclinical safety testing.

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