The combination of PET and MRI readouts in preclinical stroke provides further information on brain lesion area functionality for efficacy studies. Our comprehensive platform of acute neurology has established FDG-PET as a tool to add on the translatable imaging readouts in addition to motor testing.
Applying kinematic analysis of fine motor movement provides a more readily translatable component to the study of preclinical neurodegenerative and neuromuscular deficiencies. When employed with the MDX mouse model for DMD, this assay provides a particularly sensitive endpoint for efficacy testing.
With the SPS 2014 Annual Meeting around the corner, we prepared a poster evaluating the effect of socialization on ECG collection, using heart rate as an indicator of acclimatization to a variety of social caging scenarios.
For 15 years, SoftFocus compound libraries have pioneered the field of rationally designed focused libraries, with a new range of novel libraries designed and released each year. We are pleased to announce the completion of the 2014 collection, comprising over 30 libraries.
Our Edinburgh site has just moved its cell-based assay work into new laboratory facilities and has been developing new approaches in neutralizing antibody (NAb) and antibody-dependent cell-mediated cytotoxicity (ADCC) assays.
With the acquisition of Argenta earlier this year, Charles River's asthma expertise and portfolio has expanded to include unique models that reflect the clinical setting.
As of today, Charles River will assume management and operational responsibilities for the Frederick facility and we will continue to breed and maintain the colonies that are currently housed at this facility.
Our recent acquisition of VivoPath, a Massachusetts-based discovery CRO, along with the March 2014 acquisition of Argenta and BioFocus, has positioned Charles River as an industry leader in offering discovery services to the biopharmaceutical industry.
Co-housing is the best form of enrichment for research animals, but large animal telemetry studies routinely use animals that are individually housed during recordings, often due to hardware limitations. Our study shows that using the latest digital hardware, animals can be co-housed during telemetry recordings without loss of study sensitivity
Our newly validated ELISpot and FluoroSpot reader services are some of the most sensitive cellular assays available. With this technology, we now offer an even wider range of services to meet vaccine development needs.