We are pleased to welcome Dr. Andreas Lazaros Chryssafidis, DVM, DSc, to our Ireland facility staff. Dr. Chryssafidis has an extensive background in veterinary parasitology and the conduct of animal clinical trials, and brings more than 12 years of expertise to the Charles River team.
Dr. Kurt Sales has joined the team in Edinburgh as the new Head of Immunology. He brings a wealth of knowledge from both his academic and commercial experience to support clients.
Charles River recently validated a novel Chronic Social Defeat assay in mice. By exposing mice to an aggressive mouse, we can induce a depressive phenotype that is measured using multiple endpoints.
Science Translational Medicine recently published a paper describing a new potential drug target (ATM kinase) for the orphan indication Huntington’s disease.
In December 2014, a new chapter in the physical tests section of the United States Pharmacopeia compendium went into effect. The new content, titled Subvisible Particulate Matter in Therapeutic Protein Injections (Chapter <787>), offers an alternative to the traditional approach detailed in Chapter <788>: Particulate Matter in Injections.
Renovations to the stability suites at our site in Malvern, PA, are now complete! The facility supports our comprehensive stability testing program and offers greater capabilities for the conduct of stability studies, from IND through BLA submission.
We have established a comprehensive in vivo model for the assessment of neuropathic pain treatment options. This rat model of spinal nerve ligation (SNL)-induced neuropathy has been validated with several antinociceptive agents. With this data, we have demonstrated the model’s reliability for testing treatment effects.
With the emergence of sensitive novel kidney injury markers, we are excited to announce the availability of multiplexed assays to analyze these biomarkers in the urine of rats and large animals.
Charles River is proud to announce that its research model breeding and services facilities in France, Germany and Italy have recently received accreditation of their animal care and use programs from AAALAC International. Only a handful of commercial breeders in Europe have received this prestigious accreditation.
In response to the increase in demand for high-quality New Zealand White (NZW) rabbits, Charles River has entered into a contract breeding partnership with Oakwood Research, Inc.