In order to better understand rodent CNS disease models and the effects of drug therapy, there is a need for continuous monitoring of animals upon therapy or safety challenges. Charles River now offers telemetric recording with the use of single or multiple biopotential measurements in mice and rats for CNS drug discovery.
Our Horsham, PA site now offers on-site capabilities for GLP- compliant quantitation of large molecule biotechnology products. By leveraging the immunochemistry expertise at our Nevada and Montreal sites, our Horsham site now also streamlines our safety testing processes, providing you with improved reporting efficiencies as well as support for clinical trials.
Development toxicity testing is typically conducted in rodents, rabbits or other mammalian models. However, recent efforts to develop reliable, fast alternative models to screen compounds have produced several useful methods. Among these, a zebrafish developmental toxicity assay offers a vertebrate model of the entire embryonic period of development.
The acquisition of Argenta and BioFocus uniquely positions Charles River as an early-stage contract research organization with integrated in vitro and in vivo capabilities from target identification and validation through preclinical development.
Charles River has over 20 years of experience providing in vivo biosafety testing for clients across the world. In recognition of the pivotal role these tests provide to clients in moving their products into the marketplace, we have further expanded our in vivo testing capabilities in the US and Europe.
To better meet your study needs and help you meet your accelerated timelines, our Ohio facility has added preclinical testing space and expanded service offerings in the fields of medical device, telemeterized safety pharmacology, type I and type II diabetes, and physicochemical testing.
We can use a combination of electroretinography (ERG) and visual evoked potential (VEP) to give a full picture of visual impairment if there are test article-related effects on vision.
With our new BSL-2 housing for the conduct of short- and long-term Influenza studies in ferrets and rodents, Charles River can now provide a full portfolio of products and services for vaccine development, from influenza virus stocks to in vivo vaccine studies.
Dissemination of CNS compound effects for their interaction with the molecular target is an important step for decision making when selecting the lead compound. In addition to CNS efficacy studies, we also offer multiple tools to assess target engagement.
Announcing Biologics Testing Solutions, our comprehensive portfolio of testing for biologics development and manufacturing. Placing your biologics testing study with Charles River reduces your risk of unexpected results and will make you feel like your sample never left your hands.