Evaluate the Effects of Analgesics with Two Models of Hyperalgesia and Allodynia
Aug 06 2012
Pain is a common and disabling condition. In 2010, the international association for the study of pain reported that the cost associated with pain-related lost productive time exceeds several billion dollars per year in developed countries. Despite this, the treatment of pain is an area of largely unmet therapeutic need, with reports indicating that less than 50% of patients suffering from neuropathic pain achieve relief with any single therapy.
Assessing the efficacy of pain alleviation therapy candidates has many challenges, not the least of which is the subjective nature of pain itself. The two models discussed herein evaluate hyperalgesia in response to a chemical stimulant and allodynia response following surgically induced nerve ligation.
Charles River has recently implemented a new formalin-evoked behavioral assay and spinal nerve ligation model, both of which allow for efficient efficacy testing of relievers of hyperalgesia and allodynia.
To learn more about these methods for evaluating the effects of analgesics, please contact us at askcharlesriver@crl.com.
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