AccuGENX-ST™ - Highly Accurate Strain Analysis Through Single- and Multi-Locus Sequence Typing
Mar 25 2013
Because regulatory bodies require that manufacturers apply current good manufacturing practices (cGMP) quality control measures to ensure product safety, manufacturers must confirm that production processes are sufficiently controlled to prevent adulteration of the product and risk to consumers. In order to better help our customers meet these regulatory requirements, Charles River is pleased to now offer the Accugenix® AccuGENX-ST™.
AccuGENX-ST™ is a technique that can be used to distinguish between closely related isolates of a microbial species by comparing moderately to highly variable DNA sequences. This cGMP-compliant single- and multi-locus sequence typing method (SLST and MLST, respectively) is a more accurate, reproducible and cost-effective approach to differentiating closely related microorganisms and can be used as an alternative to ribotyping.
By using the gene sequence as opposed to the gene product (as in enzyme electrophoresis), more variation can be detected to further differentiate between closely related strains of bacteria, yeast and fungi. Not only is there a high level of microbial differentiation available by this method, but the MLST and SLST raw sequence data are also electronically retained in compliance with cGMP guidelines and can be accessed for accurate trending, tracking and comparison.
To learn more about the AccuGENX-ST™ strain typing methods, click here or contact us at askcharlesriver@crl.com or at 1.800.886.9654.
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