High-Throughput Screening for CNS Lead Compounds In Vivo
May 13 2013
Charles River has established an in vivo screening platform to provide fast and cost-effective screening of compound effects on motor behavior and brain functionality in neurological and psychiatric indications, such as schizophrenia, cognitive decline, stroke, Parkinson’s disease, traumatic brain injury, anxiety and depression. Our high-throughput screening (HTS) platform includes catalepsy and locomotor assays which offer rapid turnaround times for the comprehensive in vivo evaluation of compound effects on neurological and psychiatric behavior and functionality.
The HTS platform can be used as a screen to test the alleviation of chemically induced behaviors, such as amphetamine induced locomotor activity. The same tools, including the catalepsy assay, can also be applied to dissect unwanted side effects like extrapyramidal symptoms in rodent models.
Charles River has a significant track record in providing HTS screening in rat and mouse models. In a typical HTS program, large numbers of molecules are screened through a battery of assays and data is made available as it is generated. This facilitates quick decision making regarding the next course of action for the candidate. Data is typically delivered to clients within 48 hours of test article arrival. Charles River scientists and technicians communicate both the program logistics and scientific content with the client or the client’s team continually throughout the study.
All tests of function and behavior can be complemented and the study enhanced with rapid in vivo brain imaging. Magnetic resonance imaging (MRI) of brain lesions enables quick turnaround of stroke compound screening programs. Such acute studies using transient middle cerebral artery occlusion (tMCAO) are optimized for HTS screening purposes by our dedicated team of surgical staff and stroke experts.
To learn more about our in vivo HTS programs and all of our neurological and psychiatric models, please contact us at askcharlesriver@crl.com.
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