New Reporter Mice Scientific Webinars Available for On-Demand Viewing

Mar 08 2013

Charles River offers three mouse models through our collaboration with Transgenic Operative Products (T.O.P.) srl: repTOP™ mitoIRE, repTOP™ ERE-Luc, and repTOP™ PPRE-Luc. Luciferase genes (the reporter) have been engineered to be under the control of three different promoters which allow the in vivo imaging of physiological and pathological processes using a noninvasive technique. 

Coupled with a low signal-to-noise ratio, good reproducibility and high specificity, these models offer a versatile way to quantitatively assess both endogenous processes, such as estrogen receptor activity during the estrous cycle (repTOP™ ERE-Luc); toxicological/pathological endpoints, such as tumor development over time (repTOP™ mitoIRE); or study the role of Peroxisome Proliferator Activated Receptors (PPARs) in Amytrophic Lateral Sclerosis by crossing with hSOD1G93A mice (repTOP™ PPRE-Luc).

The following scientific webinars are now available for viewing:

  • Reporter Mice: A Way to Study Molecular Processes In Vivo
    This webinar is a general introduction to the use of reporter mice.  The concept of reporter mice is introduced and expanded upon throughout the webinar to demonstrate how the use of reporter mice may enhance research on endogenous and exogenous responses to chemical and biological insults in vivo and through time in the same animal. Click here to view the webinar. 

  • The repTOP™ mitoIRE Reporter Mouse: A Transgenic Model Suitable for Optical Imaging of Cell Proliferation in Living Mice
    This webinar is designed to introduce the researcher to the repTOP™mitoIRE reporter mouse which has been specifically developed to follow changes in proliferating cells, whether by inhibition or induction. Proliferation occurs continually throughout a lifetime, providing the turnover of cells needed to maintain the integrity of the whole animal.  Following the proliferation pathways at the physiological, pharmacological and toxicological levels in a living animal over time is a powerful tool in understanding this crucial biological response. Click here to view the webinar.

  • The repTOP™ ERE-Luc Mouse: A Unique Tool to Tackle the Complexity of Estrogen Receptor (ER) Activities
    The repTOP™ ERE-Luc mouse provides a simple way to follow the complexity of estrogen receptor activities in all tissues in the living animal over time. This webinar has been developed to share the importance of being able to follow many events regulated by the ER at the physiological, pharmacological and toxicological levels allowing researchers to visualize the effects of disruption of ER activities. This is a powerful tool in understanding the role of the ER not only throughout the estrous cycle but also throughout the life cycle. Click here to view the webinar.  

  • The repTOP™ PPRE-Luc Mouse: A Tool for the Measurement of Peroxisome Proliferator Activated Receptor (PPAR) Activity Systematically
    The repTOP™PPRE-Luc model was created to study the transcriptional activity of PPARs in vivo. The mouse carries a luciferase reporter gene under the control of a pan-PPAR receptor responsive element and was generated with a technology ensuring its ubiquitous expression and regulation.  This transgenic model is suitable for the study of PPAR’s physiopathology action and for the profiling of drugs active through this receptor family. Click here to view the webinar.

Receive an evaluation order of the T.O.P. reporter mice as part of the Charles River Model Evaluation Program, implemented to provide a risk-free, cost-effective way of determining if our models are right for your research. To place your order, complete our Model Evaluation Request Form.

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