The New AB SCIEX QTrap® 6500 LC-MS/MS System Allows Unparalleled Bioanalytical Performance
Apr 29 2013
Charles River continues to invest in the latest technologies, enabling our scientists to provide clients with the most precise and accurate data possible, on time, every time. With the recent installation of three new AB Sciex QTrap 6500 mass spectrometers in our Montreal bioanalytical laboratory, scientists have access to the highest level of LC-MS/MS performance for drug quantitation.
The performance specifications of the QTrap 6500 promise up to 10 times greater sensitivity over its predecessor, the AB Sciex QTrap 5500, and a 20-fold increase in detector dynamic range, the latter allowing drug quantitation over four orders of magnitude. Our scientists can leverage the sensitivity gains afforded by the QTrap 6500 to achieve challenging detection limits when sample volume is limited, as exemplified by dried blood spot and capillary microsampling studies, studies involving small rodents or neonatal patients and matrices such as ELF, CSF and certain tissues.
Additional LC-MS/MS sensitivity is crucial when a drug exhibits poor bioavailability, demonstrates low mass spectral ionization efficiency and/or dissociation characteristics, or cannot be extracted in high recovery. With optimized scan speeds up to 20,000 Da/sec and with polarity switching speeds of 20 msec, the QTrap 6500 is perfectly optimized for coupling with our Ultra-High Performance Liquid Chromatography (UHPLC) capabilities. With the QTrap 6500 LC-MS/MS system as a key component in our bioanalytical toolkit, we are able to support our customers’ most challenging projects, now and into the future. The QTrap 6500 and the Shimadzu Nexera LC-30AD UHPLC system are now both available for use on GLP studies with Analyst v1.6 data acquisition control.
To learn more about our newly installed QTrap 6500 systems, please contact us at askcharlesriver@crl.com.
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