Shining a Light on Digital Pathology

Sep 28 2017

In an effort to reduce your timelines, improve efficiencies, and optimize the pathologic evaluations of your specimens, we have recently completed several upgrades to our digital pathology equipment in order that we can support our electron microscopy and medical device pathology services.

Electron Microscopy

To determine a compound’s mode of action and to understand the pathogenesis of toxicologically related lesions, ultrastructural morphology procedures provide investigators with the visualization of unique details of the structure and the quantification of cellular organelles. Our new JEOL JEM - 1101 TEM (transmission electron microscope) features high resolution, contrast imaging, and optimal analytical performance which allows our pathologists to view and reconstruct 3D images of the finest cell structures. The JEOL JEM -1101 is fitted with an AMT 16 megapixel camera which provides sharp images with a high dynamic range eliminating process, reducing turnaround, and increasing our range of customization to meet your study needs. Validation of a new JEOL JEM – 1400 TEM, also equipped with an AMT 16 megapixel camera, is almost complete, providing further optimization of our electron microscopy services.

Medical Device Pathology

When preparing gross specimens for histology, high quality photo documentation is particularly important for medical device pathology in order to provide comprehensive and integrative reports that incorporate invaluable gross context with histologic findings. We have recently completed a full upgrade of our entire gross photo documentation equipment, improving the speed and efficiency of this process. The upgrade included a new DSLR Nikon 810D camera body with a 36 megapixel sensor for high-resolution, detailed images accompanied by standard and macro lenses for versatility in documenting specimens of varied size and composition; a rapidly adjustable camera stand; two high–resolution monitors for assessing photo quality in real-time; and a fully dedicated computer so that photos can then be uploaded to the server much faster. These improvements allow for higher quality images to be taken in a shorter amount of time so that we are able to illustrate the pathology and document specimen identification throughout the sample handling process.

If you have an inquiry related to imaging services or pathology evaluations for your medical device studies endpoints, please contact us at askcharlesriver@crl.com.

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