10/31/2012
The MAT works by predicting the human response to pyrogens on the basis of human fever, rather than animal models.
10/05/2012
With the addition of Accugenix, we are now able to provide you with a full line of microbial identification solutions.
10/01/2012
ICM™, our new real-time, online interface, connects clients and Charles River staff to each other − and their genetically engineered colonies.
09/24/2012
Establishing tumor models from patient-derived tumor tissue at low passage is believed to conserve original tumor characteristics such as heterogeneous histology, clinical biomolecular signature, malignant phenotypes and genotypes, tumor architecture and tumor vasculature. These models may offer preferential preservation of original patient tumor characteristics compared to more traditional cell line-derived models, and thus have the potential to lead to predictive insights when developing cancer therapies.
09/10/2012
Qualitative Mass Spectrometry (QMS) is used to identify metabolites and degredants during metabolism/environmental fate studies, as well as impurities. We recently added additional top-of-the-line equipment to expand our QMS capabilities.
09/07/2012
Charles River recently validated additional applications of expression testing to support non-GLP drug discovery research, providing early signs of efficacy and toxicity.
09/05/2012
The development of reliable inflammatory markers and in vitro assays capable of predicting in vivo cytokine release could help reduce study costs and the number of animals used for toxicology studies.
08/06/2012
The newly implemented formalin-evoked behavioral assay and the spinal nerve ligation model both allow for the efficient efficacy testing of relievers of hyperalgesia and allodynia.
08/03/2012
Our new approach for potency testing has several advantages compared to the classical ADCC approach and compliments GMP-compliant applications.
07/02/2012
The Mono-Iodoacetate (MIA) rat model of Osteoarthritis (OA) can be used identify experimental compounds with analgesic, palliative for arthritis.