04/09/2012
With a power of 80% to detect down to 6 mmHg changes in blood pressure, Jacketed External Telemetry (JET) can determine subtle hemodynamic changes while providing electrocardiographic (ECG) morphology and interval data that is equivalent to implanted telemetry.
04/02/2012
Charles River Discovery Research Services (DRS) recently validated the CVN Alzheimer’s mouse line. Researchers at Duke University Medical Center in conjunction with the Department of Medicine, Stony Brook University developed this mouse line by genetic deletion of nitric oxide synthase 2 (NOS2; iNOS) in APPSwDI mouse strains. NOS2 deletion combined with multiple amyloid precursor protein (APP) mutations enhances the pathology and drives the phenotype toward human Alzheimer’s features.
03/26/2012
Charles River's Preclinical Services (PCS) facility in Edinburgh was awarded full accreditation by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC International).
03/12/2012
Charles River’s preclinical oncology study expertise can be leveraged with Metabolon’s in-depth analysis of metabolic data to identify both mechanism of action and biomarkers.
03/07/2012
Charles River has validated the iPrecio pump for accurate and reproducible delivery of very low infusion rates in GLP-compliant safety assessment studies with nonstandard routes of administration.
03/01/2012
Charles River is delighted to announce the further expansion of field sites in Spain and Germany. These facilities augment our existing network of GLP- and GEP-accredited bases throughout the UK and Northern and Southern Europe and enhance our ability to support your agrochemical study or full program.
02/02/2012
With two high-resolution mass spectrometers, 12 radio-HPLC systems and expert biotransformation chemists, Charles River can accelerate development timelines with superior metabolic profiling and identification services. Our technology can also be applied to samples from early toxicology, in vitro and clinical samples which contain non-radiolabeled metabolites. This kind of “metabolite scouting” experiment demands a knowledge-led approach and the appropriate application of mass spectrometry. We can apply approaches designed around accurate mass screening, metabolite prediction, multi-reaction monitoring and a range of other techniques designed to give qualitative and semi-quantitative information, which is vital in toxicology species selection.
01/27/2012
This past December, Charles River’s Center for Photobiology in Pennsylvania completed the validation of its spectroradiometry system. Together with the recent validation of our state-of-the-art radiometry system, Charles River is unique to the Contract Research Organization (CRO) industry with FDA 21 CFR Part 11-compliant spectroradiometry and radiometry systems. Based on over 25 years of experience in regulatory photoxicology, these validations demonstrate our commitment to doing the best science possible for clients as they bring new drugs to market.
01/18/2012
Charles River now offers Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES) using the Perkin-Elmer Optima 8000 ICP-OES. With this technique, we can perform a variety of elemental determinations on a diverse array of samples.
01/10/2012
The Charles River Edinburgh Preclinical facility now offers a newly validated capillary microsampling method. This method reduces small animal usage for toxicology studies and helps refine data by measuring full toxicokinetic profiles for each animal. Plasma micro-sample collection is currently available; the validation for serum is underway.