Media Coverage

Creating a Culture of Care


A culture of care is critical to ensuring the humane care and use of laboratory animals. Such a culture starts with great people but requires support of senior management. Companies must recognize those that go above and beyond to ensure lab animals receive high-quality care and advance animal welfare efforts, not only benefitting the animals under our care, but our company and workplace overall.

Roundup on Research Mouse Models


GEN recently interviewed seven experts to learn just what makes a good mouse model for biopharmaceutical research and to find out for which applications and diseases better models are most needed.

The Obesity Paradox -- Seriously?


Joseph Cornicelli, a Scientific Advisor of Charles River's Discovery Services in the areas of inflammation, and metabolic and cardiovascular diseases weigh in on recent data that appear to dampen the health risks of obesity.

More True-to-Life Cell-Based Assays


Although it is too early to say if cellular models have an effect on drug attrition, more assays have been added to the testing cascade to help mitigate risk. Emphasis is placed on demonstrating target engagement and modulation. Program dependent, new assays are developed and integrated into the cascade.

Strange Ally in the War Against Sepsis


50 years ago this year, scientists first connected an ancient sea creature (horseshoe crab), to testing for life-threatening bacteria. 

John Dubczak, general manager of Charles River Laboratories’ Endotoxin and Microbial Detection division, recently shared trends in the rapid microbiological testing market, and the history of LAL-based systems in this article from Contract Pharma.

Why this crab's blood could save your life


Nearly 50 years ago, scientists discovered the horseshoe crab's clotting response to bacterial toxins. Now, its blood is harvested in huge quantities to be used in a test to ensure medical products are not contaminated.

An ancient animal's blood is a modern medical miracle


At a facility on the outskirts of Charleston, South Carolina, Charles River Endosafe® extracts the blood from horseshoe crabs. Charles River is one of four companies in the US that utilize horseshoe crabs’ blood to manufacture Limulus Amebocyte Lysate (LAL), which is used for the detection and quantification of bacterial endotoxins.

Protecting an Ancient Mariner


Limulus amebocyte lysate (LAL), a reagent that utilizes clotting enzymes extracted from horseshoe crab blood, is among the most accurate and reliable indicators of bacteria. Charles River continues to serve as an advocate for the optimal usage of LAL and conservation of this creature.

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