Media Coverage

Why this crab's blood could save your life


Nearly 50 years ago, scientists discovered the horseshoe crab's clotting response to bacterial toxins. Now, its blood is harvested in huge quantities to be used in a test to ensure medical products are not contaminated.

An ancient animal's blood is a modern medical miracle


At a facility on the outskirts of Charleston, South Carolina, Charles River Endosafe® extracts the blood from horseshoe crabs. Charles River is one of four companies in the US that utilize horseshoe crabs’ blood to manufacture Limulus Amebocyte Lysate (LAL), which is used for the detection and quantification of bacterial endotoxins.

Protecting an Ancient Mariner


Limulus amebocyte lysate (LAL), a reagent that utilizes clotting enzymes extracted from horseshoe crab blood, is among the most accurate and reliable indicators of bacteria. Charles River continues to serve as an advocate for the optimal usage of LAL and conservation of this creature.

Five Ways to Improve Host-Cell Protein Assay Performance


Arguably, the biggest challenge in making biologics is flagging unwanted host-cell proteins (HCPs) that inevitably show up in the finished product. While nano in scale, these trace amounts can be highly immunogenic and can ultimately sink a potential biopharmaceutical. As a result, manufacturers must work hard to identify and control any impurities in the final product.

What Charles River Labs' recent buys say about the future of biotech


The area’s largest preclinical research organization just got a little larger with the acquisition of two European firms. But what CEO Jim Foster said about the reason for the acquisitions says a lot about both contract research organizations and where biotech in general is headed.

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