August 6, 2012 - Pain is a common and disabling condition. In 2010, the international association for the study of pain reported that the cost associated with pain-related lost productive time exceeds several billion dollars per year in developed countries. Despite this, the treatment of pain is an area of largely unmet therapeutic need, with reports indicating that less than 50% of patients suffering from neuropathic pain achieve relief with any single therapy.
Assessing the efficacy of pain alleviation therapy candidates has many challenges, not the least of which is the subjective nature of pain itself. The two models discussed herein evaluate hyperalgesia in response to a chemical stimulant and allodynia response following surgically induced nerve ligation.
Charles River has recently implemented a new formalin-evoked behavioral assay and spinal nerve ligation model, both of which allow for efficient efficacy testing of relievers of hyperalgesia and allodynia.
Please view our Models of Hyperalgesia and Allodynia Technical Sheet to learn more. (Technical sheet is available only on The Source℠. Click here to log in or click here to register.)
To learn more about these methods for evaluating the effects of analgesics, please contact us at email@example.com.
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We offer a package of well-established, state of the art in vitro mode of action assays that are suitable for early phase biocomparability studies, lot release and stability. These tests can accelerate the time it takes to get a new product ready for market submission.
Charles River has developed and optimized the RT-PCR test for vertically-transmitted poultry pathogens for testing SPF flocks as defined by the PhEur 5.2.2.
May 20–May 22
Please visit Charles River tabletop #611 to discuss our full portfolio of products and services, including our Preclinical Services, as well as our Biopharmaceutical Services, which deliver client-focused solutions for the specific testing and manufacturing requirements of your biologic.
May 23–May 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.