Harnessing Expression Testing for Drug Discovery Research
September 7, 2012 - Charles River has historically utilized real-time PCR for the purpose of zygosity testing of transgenic animals, single integration analysis, copy number determination and expression testing of an overexpressed gene. Our Genetically Engineered Models and Services (GEMS) team recently validated additional low density (TLDA) and mid-density (OpenArray®) expression testing platforms to support non-GLP drug discovery research for clients in the pharmaceutical sector. Expression testing can provide early signs of efficacy and toxicity, confirming or refuting theories for indication and therapeutic area.
Expression profiling data has proven useful in safety lead optimization and dose-limited toxicity studies. Utilizing our high-throughput platforms and pre-validated assays, GEMS can perform studies that involve multiple dose groups with samples from several organ systems, including liver, kidney, heart and skeletal muscle. This method allows us to assay a large number of target genes following treatment, providing clients with early indications of toxicity and efficacy before moving on to more intensive and costly studies of other species.
To learn more about how to leverage our expression testing services in your drug discovery research, email email@example.com.
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Clinical pathology data can assist you in selecting the most appropriate model for your study and can provide important information on the physiology and health of your research animals.
We are now the exclusive distributor of the TARGATT™ mouse. The TARGATT mouse is a transgenic mouse designed to produce animal models with investigator designed exogenous DNA sequences knocked-in to a specific site.
Jun 10–Jun 13
Visit us in booth #091 to learn more about our recent innovations including expanded diagnostic capabilities, a new online portal connecting clients with their colonies and a deep-rooted commitment to humane care.
May 28–Jun 01
The International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) are excited to sponsor the second joint scientific meeting by the two organizations.
May 23–May 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.