Methylazoxymethanol (MAM) Acetate-Induced Model for Schizophrenia Research Now Available
August 13, 2012 - Exposure of pregnant rats (multiple strains) on gestational day (GD) 17 to methylazoxymethanol (MAM) acetate results in disrupted neurogenesis in offspring that later in life show subtle behavioral changes, cognitive deficits, neurochemical changes and neuropathology that mimic those seen in schizophrenia patients. The MAM rat model is a valuable research tool, useful in identifying drug candidates that would not be discovered through traditional screens for antipsychotics. In addition, the model shows value as a developmental model to be used to identify genes that may be contributory in abnormal cortical neurogenesis and function.
To learn more about this surgical model, click here. For more information on our MAM acetate-induced model, as well as other neurological procedures, please contact us at email@example.com.
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Clinical pathology data can assist you in selecting the most appropriate model for your study and can provide important information on the physiology and health of your research animals.
We are now the exclusive distributor of the TARGATT™ mouse. The TARGATT mouse is a transgenic mouse designed to produce animal models with investigator designed exogenous DNA sequences knocked-in to a specific site.
Jun 10–Jun 13
Visit us in booth #091 to learn more about our recent innovations including expanded diagnostic capabilities, a new online portal connecting clients with their colonies and a deep-rooted commitment to humane care.
May 21–May 24
RDD Europe 2013 is a forum for pulmonary and nasal drug delivery experts from all around the world to exchange scientific knowledge and expertise.
May 23–May 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.