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Methylazoxymethanol (MAM) Acetate-Induced Model for Schizophrenia Research Now Available
August 13, 2012 - Exposure of pregnant rats (multiple strains) on gestational day (GD) 17 to methylazoxymethanol (MAM) acetate results in disrupted neurogenesis in offspring that later in life show subtle behavioral changes, cognitive deficits, neurochemical changes and neuropathology that mimic those seen in schizophrenia patients. The MAM rat model is a valuable research tool, useful in identifying drug candidates that would not be discovered through traditional screens for antipsychotics. In addition, the model shows value as a developmental model to be used to identify genes that may be contributory in abnormal cortical neurogenesis and function.
To learn more about this surgical model, click here. For more information on our MAM acetate-induced model, as well as other neurological procedures, please contact us at askcharlesriver@crl.com.
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Methylazoxymethanol (MAM) Acetate-Induced Model for Schizophrenia Research Now Available
The MAM rat model is a valuable research tool, useful in identifying drug candidates that would not be discovered through traditional screens for antipsychotics.