Monocyte Activation Test (MAT) Now Available from Charles River
March 23, 2011 - Charles River is committed to expanding our portfolio with in vitro alternatives to in vivo tests. We now offer the Monocyte Activation Test (MAT) according to EP 2.6.30. The MAT works by predicting the human response to pyrogens on the basis of human fever rather than animal models. This test may be used as an alternative to the rabbit pyrogen test. The MAT can test for Gram-positive and Gram-negative organisms, other biological pyrogens (e.g., yeast), as well as parasitic and viral pyrogens.
The expansion of the current services provides clients with the opportunity to work closely with our team of experienced staff for release of their product and to explore alternative methods to assess the pyrogenicity of their materials. Following a product specific validation, the MAT may be used for products such as drugs that affect body temperature regulation (e.g., antipyretic drugs and steroids), drugs that cause immunological reactions (e.g., immunoglobulins), detergents and some blood-derived products (e.g., stem cells). The MAT can also be considered in place of other methods currently used to test products that are turbidimetric, strongly colored or interfere with clotting. The MAT quantifies substances that activate human monocytes or monocytic cell lines to release endogenous mediators, such as pro-inflammatory cytokines.
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We offer a package of well-established, state of the art in vitro mode of action assays that are suitable for early phase biocomparability studies, lot release and stability. These tests can accelerate the time it takes to get a new product ready for market submission.
Charles River has developed and optimized the RT-PCR test for vertically-transmitted poultry pathogens for testing SPF flocks as defined by the PhEur 5.2.2.
May 20–May 22
Please visit Charles River tabletop #611 to discuss our full portfolio of products and services, including our Preclinical Services, as well as our Biopharmaceutical Services, which deliver client-focused solutions for the specific testing and manufacturing requirements of your biologic.
May 23–May 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
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This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.