August 31, 2011-
Coagulation Factor Measurement to Support Toxicokinetic Analysis
The Clinical Pathology Department at Charles River Montreal recently analyzed a compound known to be a recombinant coagulation factor. It represents the first time a recombinant coagulation factor’s biological activity has been analyzed within our clinical laboratory. Overall, the analytical method used is one of many our multiple preclinical laboratories aim to expand on.
To assess the activity of this specific recombinant coagulation factor, toxicokinetic (TK) samples from toxicology studies were analyzed. The analytical method was applied to one of our standard coagulation analyzers within the clinical laboratory and the results of the factor’s activity were analyzed and reported by the TK group. The analytical method was adapted from the sponsor and is fully validated.
Bone Marrow Cytology Assessment
When there are indications of hematotoxicity in a toxicity study, cytological assessment of bone marrow smears can provide valuable information. Veterinary clinical pathologists at Charles River Montreal were involved in a recent publication titled “Best practices for the evaluation of bone marrow in non-clinical toxicity studies,” which appeared in a recent issue of The Journal of Toxicologic Pathology (Reagan et al, 2011).
In the evaluation of bone marrow smears a quantitative assessment–typically a 300 cell count–is performed. The quantitative assessment also includes a calculation of the myeloid to erythroid ratio. In addition, an evaluation involves a qualitative assessment. This aspect provides information on cellular morphology as well as maturation of hematopoietic cell lineages. At the conclusion of an evaluation, a bone marrow report is provided with an interpretation of the data, which includes correlations with any potential findings within the hematology and anatomic pathology results. This service is available at all Charles River Preclinical Services laboratories.
For additional information on this study or our clinical chemistry capabilities, please contact us at 1.877.CRIVER.1 or email@example.com.
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We have established an in vivo screening platform to provide fast and cost-effective screening of compound effects on motor behavior and brain functionality for the study for central nervous system diseases.
We offer a package of well-established, state of the art in vitro mode of action assays that are suitable for early phase biocomparability studies, lot release and stability. These tests can accelerate the time it takes to get a new product ready for market submission.
May 21–May 24
RDD Europe 2013 is a forum for pulmonary and nasal drug delivery experts from all around the world to exchange scientific knowledge and expertise.
May 23–May 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.