Charles River Genetic Testing Services: New mouse 384 SNP marker panel
September 27, 2010 - Backcrossing your animal model to a defined background reduces genetic variability and is an essential step in the research process. Charles River's MAX-BAX® (Marker-Assisted Accelerated Backcrossing) service dramatically reduces the time normally required to fully backcross a line. We are now pleased to offer the next generation of accelerated backcrossing technology with our new mouse 384 single nucleotide polymorphism (SNP) marker panel.
Our new SNP panel, composed of 384 carefully selected SNP markers, was designed to maximize polymorphism between common strains and provide even coverage of the mouse genome. Markers are spaced at approximately 7 Mbp intervals, and about 200 markers will be polymorphic between any given strains, which is almost twice the density of our microsatellite panels. Our new SNP panel is ideally suited to our MAX-BAX® service. Using our 384 SNP marker panel to select preferred breeders in your backcrossing project will reduce the number of generations needed to produce a congenic strain from ten to just five, enabling you to start your experiments faster. The entire genome is analyzed at each generation, which may make unexpected genetic variation or breeding errors easier to detect. The 384 SNP marker panel can be used for any donor and recipient strains. This new panel can also be used for inbred and outbred strain characterization, as well as mapping.
Like our 32 SNP marker genetic quality control panel, the testing for the 384 SNP marker panel is performed on an Applied Biosystems OpenArray® platform using robust fluorescence-based TaqMan® SNP genotyping assays. By utilizing nanoliter fluidic technology, we are able to offer this new panel at a substantial savings, enabling you to devote more funds to other aspects of your research. The sample submission procedure is simple and straightforward; you may send samples directly to our genetic testing laboratory or have the breeding performed by Charles River. Results are returned by email along with a detailed analysis and breeding suggestions, and our scientific staff is always available to answer questions. We provide a quick turnaround time to accelerate your research.
With this new panel, we continue the Charles River tradition of providing high-quality services at the most competitive prices. We will continue to offer our 32 SNP marker panel for routine genetic quality control of inbred mouse strains and our standard and custom microsatellite panels for mapping, fine mapping, accelerated backcrossing, background strain characterization, and inbred substrain characterization. In one single step, Charles River can make the process of backcrossing your mouse strain faster, more affordable, and more effective than ever before.
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Clinical pathology data can assist you in selecting the most appropriate model for your study and can provide important information on the physiology and health of your research animals.
We are now the exclusive distributor of the TARGATT™ mouse. The TARGATT mouse is a transgenic mouse designed to produce animal models with investigator designed exogenous DNA sequences knocked-in to a specific site.
Jun 10–Jun 13
Visit us in booth #091 to learn more about our recent innovations including expanded diagnostic capabilities, a new online portal connecting clients with their colonies and a deep-rooted commitment to humane care.
May 28–Jun 01
The International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) are excited to sponsor the second joint scientific meeting by the two organizations.
May 23–May 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
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This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
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