Now Available – Reporter Mice: A Way to Study Molecular Processes In Vivo
October 26, 2012 - Charles River Genetically Engineered Models and Services (GEMS) is now offering three new mouse models through our collaboration with Transgenic Operative Products (T.O.P.) srl. Receive an evaluation order of the T.O.P. reporter mice as part of the Charles River Model Evaluation Program, implemented to provide a risk-free, cost-effective way of determining if our models are right for your research. To place your order, complete our Model Evaluation Request Form.
Luciferase genes (the reporter) have been engineered to be under the control of three different promoters which allow the in vivo imaging of physiological and pathological processes using a noninvasive technique. Coupled with a low signal-to-noise ratio, good reproducibility and high specificity, these models offer a versatile way to quantitatively assess both endogenous processes, such as estrogen receptor activity during the estrous cycle (repTOP™ ERE-Luc); toxicological/pathological endpoints, such as tumor development over time (repTOP™ mitoIRE); or study the role of Peroxisome Proliferator Activated Receptors (PPARs) in Amytrophic Lateral Sclerosis by crossing with hSOD1G93A mice (repTOP™ PPRE-Luc).
The noninvasive nature of the bioluminescent readout allows for multiple readouts for both short-term and long-term studies in the same animal, thus minimizing inter-animal variation and potentially using fewer animals per study. In some cases, such as in the induction of skin cancer, the animal can act as its own control, with vehicle being administered on one side and the tumorigenic agent on the other.
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Our study, presented at the 2013 Experimental Biology Conference, focuses on the phenotype and genotype comparison for C57BL/6N substrains contributing to the International Mouse Phenotyping Consortium (IMPC).
Clinical pathology data can assist you in selecting the most appropriate model for your study and can provide important information on the physiology and health of your research animals.
Jun 21–Jun 25
This five-day meeting draws diverse professionals from around the world to share their breakthroughs in the prevention, diagnosis and treatment of diabetes.
Jun 28–Jun 28
Charles River offers a wide range of seminars, workshops and training courses for animal technicians, veterinarians, biologists and laboratory technicians who work with laboratory animals. For more information about our course on animal health monitoring, click "view more" below.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.