In Vitro Models for Dermal Corrosion / Irritation and Eye Irritation Offered by Charles River
May 7, 2010 – As part of our continued commitment to the 3Rs (to reduce, refine and replace animals in research), we have evaluated in vitro models for dermal corrosion and irritation as well as eye irritation and are pleased to add these new assays to our portfolio of tests to help accelerate the development of your compound. The three models evaluated and available for use are:
In vitro models of skin and eye irritation/corrosivity have considerable advantages for the chemical and pharmaceutical industries. While in vivo testing of non-irritants is necessary, these in vitro assays can help identify corrosive or irritant compounds while minimizing animal use and distress, in line with our ongoing commitment to animal welfare.
These assays can also lead to lower test item usage, because testing can be performed using as little as 100 mg of compound. They also have high predictive power; published validations of these models have demonstrated their ability to identify corrosive and irritant compounds from many different chemical classes.
In addition, an acknowledged challenge with animal models is that there is a basic difference in biology between species. Since these in vitro models are derived from human tissues or cell lines, histology shows them to be very similar to the human tissues that they represent.
For more information about these assays or any of our products and services, contact us at email@example.com.
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We offer a package of well-established, state of the art in vitro mode of action assays that are suitable for early phase biocomparability studies, lot release and stability. These tests can accelerate the time it takes to get a new product ready for market submission.
Charles River has developed and optimized the RT-PCR test for vertically-transmitted poultry pathogens for testing SPF flocks as defined by the PhEur 5.2.2.
May 20–May 22
Please visit Charles River tabletop #611 to discuss our full portfolio of products and services, including our Preclinical Services, as well as our Biopharmaceutical Services, which deliver client-focused solutions for the specific testing and manufacturing requirements of your biologic.
May 23–May 23
This full-day seminar encompasses selected topics from our Charles River Short Course on Laboratory Animal Science. We would like to acknowledge Michigan State University for hosting this event and extend our heartfelt thanks to guest speaker Dr. Danielle Ferguson.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.