Study on Rat MI Model Yields Results
2011 Charles River study shows ischemic lesion can be reliably produced in 70% of rat myocardial infarction models
October 20, 2011 - Coronary artery disease is the leading cause of death worldwide. The primary cause of this disease and subsequent heart failure is atherosclerosis of coronary arteries leading to occlusion and ischemic damage to the heart muscle.
Charles River Surgical Services performed a study to characterize the rat myocardial infarction model. The goal of the project was to document the expected size of ischemic lesion following ligation of the left anterior descending (LAD) coronary artery in the CD® rat. Forty-two male CD® rats [Crl:CD(SD)] weighing 175-200 grams underwent surgical ligation of the LAD coronary artery, followed by measurement of the resulting ischemic lesion. Results showed that an ischemic lesion comprising 20-30% of total cardiac tissue can be reliably produced in at least 70% of the animals that underwent surgery.
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This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
Charles River Laboratories, Inc.