New therapies to promote bone healing or treat osteoporosis, arthritis and other skeletal diseases require a comprehensive preclinical assessment of bone and cartilage. Bone endpoints can be incorporated into toxicology programs to fully evaluate test articles that have an intended effect on bone or to determine effects of test articles that have secondary, indirect or adverse effects.
Charles River offers services in the area of bone/skeletal research that combine established discovery and preclinical program development expertise with a host of novel bone research technologies that provide highly specialized evaluations of bone disease and bone quality. Our skeletal research scientists can assess the effect of a drug in vivo or ex vivo on bone at toxicological and pharmacological doses and facilitate the interpretation of study findings to help you better design clinical trials.
Bone Research Services
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In this article, Charles River Senior Scientific Director Susan Y. Smith discusses the skeleton’s function in human physiology. "We lose weight: we lose bone; we build muscle: we build bone; we become diabetic: bones become fragile," wrote Smith. "Bone fragility and treating the consequences of fracture is a major public health concern costing millions of annual tax dollars, underscoring the need to ensure that nutraceuticals and pharmaceuticals are safe or beneficial for the skeleton."
Our newest Accugenix® tech note provides insight into the various methods of fungal identification and their limitations. The need to establish an environmental monitoring program with access to a relevant and accurate microbial reference library is also discussed.
Jun 21–Jun 25
This five-day meeting draws diverse professionals from around the world to share their breakthroughs in the prevention, diagnosis and treatment of diabetes.
Sep 12–Sep 13
Standard Operating Procedures (SOPs) are an integral part of a successful quality system as they provide individuals with the information to perform a job properly and facilitate consistency in the quality and integrity of a product or end result.
Jun 28–Jun 28
Charles River offers a wide range of seminars, workshops and training courses for animal technicians, veterinarians, biologists and laboratory technicians who work with laboratory animals. For more information about our course on animal health monitoring, click "view more" below.
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
Charles River Laboratories, Inc.