Inappropriately triggered or incompletely controlled inflammatory responses are a major cause of disease, impaired quality of life and morbidity. Charles River Discovery Services has the experience and expertise to help advance your understanding of the cellular processes involved and identify therapeutic targets and markers of disease to develop new approaches for diagnosis, prevention and treatment.
Additionally, the role of inflammation in such widespread chronic diseases such as atherosclerosis, metabolism and diabetes is an area of intense investigation. Our scientists offer in-depth expertise involving the interplay of these diseases and the impact of inflammation in these therapeutic areas. With an expansive catalog of high-quality in vitro, biomarker, PK and toxicology services, we provide seamless drug development for your discovery program.
Available inflammation models for evaluation of your test articles include the following:
Carrageenan Footpad Edema (CFE)
Delayed-Type Hypersensitivity (DTH)
LPS-Induced Cytokine Release
Thioglycollate-Induced Peritonitis (TIP)
Bleomycin-Induced Pulmonary Fibrosis
Experimental Autoimmune Encephalomyelitis (EAE)
Trinitrophenyl-ovalbumin immunization (TNP-OVA)
Acute Lung Injury
Rat collagen-induced arthritis (rCIA)
Mouse collagen-induced arthritis (mCIA; with or without LPS synchronization)
Mouse collagen antibody-induced arthritis (CAIA)
Adjuvant/pristine-induced arthritis (AIA)
With extensive drug development experience driving our model validation, Charles River is able to offer study models that ensure disease progression as well as positive control and standards of care responses. In addition, our wide range of supporting analysis can expand your study outcomes for faster, more effective analysis of your drug candidates.
For more information on how we can support your inflammation research, please contact us at 1.877.CRIVER.1 or firstname.lastname@example.org.
Discovery Services Overview
Inflammation and Immunology Datasheet
Rheumatoid Arthritis Datasheet
Cardiovascular Diseases Technical Sheet
Central Nervous System Datasheet
Models of Behavior Datasheet
Webinar Replay - Markers of Inflammation - (June 2011)
Webinar Replay - Preclinical Pulmonary Inflammation Models (October 2010)
Webinar Replay - Inflammation Models in Preclinical Drug Research: Traditional Endpoints to Translational Imaging (September 2010)