metabolite profiling & identification
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Charles River offers a comprehensive and integrated service for the isolation, analysis and identification of metabolites from biological matrices in support of compound safety and metabolism studies.
Our biotransformation chemists have many years of experience in the following areas:
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Chromatography method development
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Sample preparation method development
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Extraction of bound residues
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Radio-chromatographic profiling
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Isolation and purification of metabolites
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Metabolite identification using LC-MS/MS, QToF and IT-ToF for accurate mass and access to NMR
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Expert report preparation
Radiosynthesis
Charles River can assist with the procurement of radiolabelled molecules on behalf of clients. On request, we will be pleased to obtain estimates from specialist synthesis laboratories and will monitor progress through to delivery to our site. This service is totally confidential, free of charge and does not commit the client to using either Charles River or any of the laboratories involved. Additionally, we have chemists on-site who are experienced in the handling and repurification of radiolabelled molecules, should that service be required. This allows us to preserve study timelines when radiolabelled molecules are unstable or impure.
For more information about our metabolite profiling and identification services, contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.
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Metabolite, metabolites, metabolite profiling, metabolite identification, metabolism, biotransformation, purification, Chromatography, method development, Sample preparation, Radio-chromatographic, LC-MS/MS, QToF, IT-ToF, NMR, Radiosynthesis, synthetic chemistry, repurification, radiolabeled, reference standards
Metabolite Profiling & Identification | Animal Health Product Development | Charles River
Charles River offers a comprehensive and integrated service for the isolation, analysis and identification of metabolites from biological matrices in support of compound safety and metabolism studies.