Biopharmaceutical Testing Services | Charles River

PCR 

The rapid detection and identification of contaminants in intermediates and final product is essential to accelerate biopharmaceutical product pipeline development. Charles River Biopharmaceutical Services (BPS) offers nucleic acid amplification technology (NAT)-based detection and quantification methods, such as PCR and RT-PCR, to detect the presence of bacterial, viral and host cell nucleic acids and ensure safety. PCR is an established, highly sensitive, reliable, time-efficient method that can be validated for the detection and identification of contaminants. NAT-based methods can also be applied to cell line characterization and process validation.

Applications of PCR include:

  • Mycoplasma detection validated according to European Pharmocopeia guidelines
  • Residual DNA analysis for a wide range of species
  • Viral nucleic acid detection
  • Microbial identification by PCR and DNA sequencing
  • Plasmid copy number analysis of recombinant target sequences in microbial and mammalian systems
  • Genetic stability
  • Retroviral enzyme activity (reverse transcriptase)


For more information, please contact us at askcharlesriver@crl.com or 1.877.CRIVER.1.

Discover the full range of Charles River Products and Services

For more information please call:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

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Jul 29 - CR and WuXi Terminate Agreement
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Sep 08-Sep 11 - Kyoto, Japan - 2010 World Molecular Imaging Congress
Sep 13-Sep 15 - San Diego, CA - 16th Annual Symposium on Biotechnology-Derived Therapeu...
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Charles River Laboratories, Inc.