Central Nervous System (CNS) Mouse and Rat | Charles River Discovery Services

Amyotrophic Lateral Sclerosis (ALS) Model 

Transgenic SOD1 (superoxide dismutase 1) mice express a G93A mutant form of human SOD1. SOD1 mice (TgN-SOD1-G93A-1Gur) exhibit a phenotype similar to amyotrophic lateral sclerosis (ALS) in humans, an age-related rapidly progressive decline of motor functions accompanied by degenerative changes of motoneurons within the spinal cord, brain stem and neocortex. Charles River Discovery Research Services has negotiated the license to employ the transgenic material from Northwestern University/Harvard/MIT for third parties. All characterization and analytical methods used with the model are performed in our proprietary labs by our own staff of scientists and technicians.

Example Study Paradigm of ALS Mouse Model

Schematic of study paradigm of transgenic SOD-1 (superoxide dismutase 1) mouse model of ALS

Click here to view an example study paradigm of our transgenic SOD1 (superoxide dismutase 1) mouse model of ALS.

 

Study Components with SOD1 Mice


Optional Study Components with SOD1 Mice 

  • MRI for neurodegeneration in the brain stem
  • MRS for metabolic changes in the brain stem
  • Motor neuron counts

 

For more information about our transgenic SOD1 mouse model for ALS research, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.

Charles River also offers an in vitro ALS model that is created by exposing a spinal cord cell culture to Kainic acid. For more information, click here.

Discover the full range of Charles River Products and Services
The Source

For more information, contact us at:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

view all

News & Events

view all
May 08 - Comparability Studies for Monoclon...
May 02 - Real Time Polymerase Chain Reactio...
May 20-May 22 - San Diego, CA - 2013 American Association of Pharmaceutical Scientists ...
May 23-May 23 - East Lansing, Michigan, USA - The Ins and Outs of Transgenic Colongy Ma...

Charles River Laboratories, Inc.