Central Nervous System (CNS) Mouse and Rat | Charles River Discovery Services

Migraine Models 

Charles River Discovery Services has a wealth of experience in the area of modeling the human condition of migraine in vivo. The electrical stimulation of the trigeminal ganglion induces changes in cerebral blood flow (CBF) observed in migraine as well as changes in plasma protein extravasation and levels of CGRP. The chemical induction of cortical spreading depression by application of KCl also induces changes in CBF as well as changes in direct current potential and CGRP release.

Models for Migraine

  • Cortical Spreading Depression (KCI-Induced)
  • Trigeminal Ganglia Electrostimulation


Example Study Paradigm of CSD Model

Diagram outlining an example migraine study paradigm using our Cortical Spreading Depression (CSD) model

 

Click here to see a diagram outlining an example study paradigm using our Cortical Spreading Depression (CSD) model.

 

Data

DC Potential Change (mV) and CBF Change (%) in Migraine Model

 

 
DC Potential Change (mV) and CBF Change (%)

  

Number of Extracellular DC Potentials

 

Number of Extracellular DC Potentials



Magnitude of Cerebral Blood Flow (CBF) Change (1% from the Baseline) in Migraine Model

 

Magnitude of CBF Change (1% from the Baseline)

 


For more information about our models used to research migraines, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.

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For more information, contact us at:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

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