Charles River Discovery Services has a wealth of experience in the area of modeling the human condition of migraine in vivo. The electrical stimulation of the trigeminal ganglion induces changes in cerebral blood flow (CBF) observed in migraine as well as changes in plasma protein extravasation and levels of CGRP. The chemical induction of cortical spreading depression by application of KCl also induces changes in CBF as well as changes in direct current potential and CGRP release.
Models for Migraine
- Cortical Spreading Depression (KCI-Induced)
- Trigeminal Ganglia Electrostimulation
Example Study Paradigm of CSD Model
Click here to see a diagram outlining an example study paradigm using our Cortical Spreading Depression (CSD) model.
DC Potential Change (mV) and CBF Change (%)
Number of Extracellular DC Potentials
Magnitude of CBF Change (1% from the Baseline)
For more information about our models used to research migraines, please contact us at 1.877.CRIVER.1 or firstname.lastname@example.org.