Inflammation Models | Charles River Discovery Research Services

Carrageenan Footpad Edema (CFE) Model 

Carrageenan Footpad Edema (CFE) is a classic model of acute inflammation. It is a general model for the assessment of overall inflammation and it can also be used as a method to assess acute inflammatory pain. This model provides rapid assessment of a compound’s ability to provide anti-inflammatory and analgesic activity. Agents that show activity in this assay include NSAIDs, glucocorticoids, and coxibs (modest).

Animals are treated with compound prior to challenge with λ-carrageenan in one hind footpad. The contralateral footpad is injected with saline. Footpad thickness is measured at specified time points. Determination of tissue and/or serum cytokine levels and histologic analysis can also be performed.

Data

Footpad Swelling in CFE
  Footpad Swelling on CFE 

 

 

 

Total Disease Burden in CFE

 

                   Total Disease Burden in CFE

 


 

 

 

For more information about our Carrageenan Footpad Edema (CFE) model, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.

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