Inflammation Models | Charles River Discovery Research Services

LPS-Induced Cytokine Release Model 

Our validated lipopolysaccharide (LPS) model is easily modified to address client-specified study needs. For our initial validation study, each mouse receives a LPS injection. At specified time points post-LPS challenge, animals are euthanized and blood collected for cytokine analysis. Animals in the validation experiment below were euthanized at 0.5, 1, 2, 4 and 8 hrs post-LPS challenge. Client studies would compare treated groups against control animals.

Data

Chart of Plasma G-CSF, IL-6 and TNF Response to LPS Challenge in Mice

 

 

Chart of Plasma G-CSF, IL-6 and TNF Response to LPS Challenge in Mice

 

   LPS Induced Cytokine Release

 

LPS-Induced Cytokine Release

 


For more information about our LPS-Induced Cytokine Release model, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.

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For more information, contact us at:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

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