Rheumatoid Arthritis (RA) Mouse and Rat Models | Charles River Discovery Research Services

Rheumatoid Arthritis (RA) Mouse and Rat Models 

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks the joints (but may affect many tissues and organs), producing an inflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints. There are a number of animal models in both mice and rats that are used to screen compounds against the effects of RA.

Rheumatoid Arthritis Models

Model Details
Rat Collagen-Induced Arthritis (CIA) 28-day model carried out in Dark Agouti or Lewis rats using bovine or porcine type II collagen as an immunogen.
Mouse Collagen-Induced Arthritis (CIA) 49-day model carried out in DBA1 mice using bovine or chicken type II collagen as an immunogen. Disease onset can be synchronized with LPS challenge.
Mouse Collagen Antibody-Induced Arthritis (CAIA) 21-day model by passing the development of anti-collagen antibodies. Disease is induced using a cocktail of monoclonal antibodies directed against type II collagen.
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