A defect in the leptin receptor is responsible for the diabetic phenotype exhibited by ZDF rats. Male ZDF rats become diabetic when fed Purina Diet 5008. Initially, the animals are normoglycemic and hyperinsulinemic. With time, pancreatic beta cell function declines and plasma insulin levels drop, producing diabetes. The animals become obese, hyperglycemic, hypertriglyceridemic and exhibit impaired glucose tolerance. Female ZDF rats can also be converted to the diabetic phenotype by feeding an appropriate diet. This model is currently under development in our laboratories.
Effect of Standard Agents on Non-Fasting Blood Glucose in ZDF Rats
Effect of Standard Agents on Plasma Adiponectin in ZDF Rats
Effect of Standard Agents on Plasma FFA in ZDF Rats
Effect of Standard Agents on Plasma Triglycerides in ZDF Rats
Effects of Standard Agents on Glucose Tolerance in ZDF Rats
For more information about our ZDF rat models, please contact us at 1.877.CRIVER.1 or firstname.lastname@example.org.