The study and development of anti-angiogenic therapies depends on reliable and reproducible stimulation models of neovascular response. Charles River Discovery Services has several experimental techniques that allow an effective examination of short-term neovascularization and angiogenic response to bFGF, VEGF or other angiogenic stimuli.
Corneal Micropocket Assay
- Hydron pellet prepared with growth factors chosen for specific study requirements
- Surgical implantation of pellet into a corneal micropocket
- Corneal neovascularization measured using slit-lamp microscope
- Short-term study with rapid turnaround times
bFGF and VEGF Day 6
In vivo screens using angiogenic-dependent tumor growth.
- Bevacizumab can be used as a positive control.
Metronomic dosing (Browder, 2000; Cancer Research 60:1878)
- Long-term, low-level dosing of cytotoxics or other agents of interest to inhibit growth and development of vascular endothelium while avoiding whole-animal toxicity
- Metronomic dose determination for use in efficacy study
- Studies can last up till 90 days.
For more information about our angiogenesis models, please contact us at 1.877.CRIVER.1 or firstname.lastname@example.org.