The Yoshida ascites hepatoma model induces cachexia and produces tissue wasting, particularly in skeletal muscle. This very aggressive, short-term model is used to evaluate the anti-cachectic effects of a therapy. With therapies typically beginning on the first day and continuing to the end of the study, heart, gastrocnemius and ascites are measured at sacrifice and used to evaluate efficacy of the therapy.
For more information about our cachexia model, please contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.
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Cachexia Model | Charles River Discovery Services
Charles River’s Yoshida ascites hepatoma model induces cachexia and produces tissue wasting, particularly in skeletal muscle, making it a good model to evaluate the anti-cachectic effects of chemotherapy.