For over 20 years, Charles River has been conducting efficacy studies to support early ocular drug development. Our expert staff works with local board-certified veterinary ophthalmologists and leading-edge technologies, such as optical coherence tomography (OCT), to provide unmatched ophthalmic drug discovery services.
- Administration Methods – From routine topical instillation to more complex intravitreal and surgical interventions (internal/external implants and transplants), we can perform studies in ocular animal models through several methods of administration. Other methods include subretinal, intracameral, subconjunctival and subtenon injections.
- Compound Classes – Studies can be performed for multiple classes of drugs, including proteins, antibodies, oligonucleotides, siRNA, cell-based therapies, viral vectors, implants, steroids and numerous other small molecules targeting all major ocular diseases.
- Support Services for Ocular Programs – We offer a portfolio of supplementary services to support your ocular program: electroretinography, tonometry (IOP) evaluations, digital fundus photography, pachymetry (corneal thickness measurement), vitrectomy, quantitative autoradiography, drug metabolism techniques and enhanced microscopic evaluation.
- The Latest Ocular Technology and Assessments – Our staff utilizes the newest technology available, such as optical coherence tomography, ultrasonic corneal thickness and specular microscopy for in vivo evaluation of the corneal endothelium. We also provide bioanalytical and immunology laboratory services and pathology services.
Ocular Animal Models
- Glaucoma models (normotensive)
- Optic nerve crush
- Normotensive eye, no
- Glaucoma models (hypertensive)
- Laser damage to
- Intravitreal hypertonic
- Anterior uveitis model
- Lipopolysaccharide (LPS)-induced
- Age-related macular degeneration (AMD) model
- Laser-induced choroidal
- Corneal neovascularization models
- Corneal micropocket
- Diabetic retinopathy model
- Streptozotocin (STZ)-
- Light damage model
|In Vitro Toxicology Models|
- In vitro human corneal epithelium (HCE)
- SkinEthic HCE model
To learn more about services and ocular animal models to support your ophthalmic drug discovery, click here to contact an expert.
Related Ocular Research Information
Data Sheet: Ocular Research and Toxicology Studies(Available only in The Source℠. Click here to log in or click here to register.)