Our experience covers a vast array of formulation types, including oral, parenteral, creams, ointments, and inhalation products such as nebulizer solutions and powder blends.
Formulation assessments:
- pH solubility
- pH partitioning
- Excipient compatibility
- Dosability and suitability
- Container compatibility
- Microscopic behavior
- Bioavailability enhancement
- Analytical chemistry
For future development of your lead compound or compounds, test articles can be stored; formulated; and their concentration, purity, and stability verified to support your GLP preclinical and clinical formulation requirements.
Bioanalysis
The speed of lead candidate selection studies requires an equally rapid analytical tool to efficiently measure drug concentrations in the biological samples collected. Charles River offers non-GLP discovery bioanalytical services either in support of studies conducted in-house or as a stand-alone service with the flexibility and speed to meet the timelines and diverse needs for discovering the best drug candidate.
Our research-grade assay approach via LC-MS/MS can quickly analyze samples for compound ranking. Once a lead candidate has been selected in the discovery analytical process, these methods can be transferred to method development for GLP bioanalytical testing including feasibility, validation, and preclinical and clinical sample analysis.