Discovery and Imaging Services | Charles River

 

laboratory sciences


 
 

Each well-designed in vitro and in vivo testing program for discovery purposes must have the appropriate analytical tools to obtain meaningful data and be successful in selecting the most promising compounds. Charles River has a global network of laboratory services to meet all your discovery needs.

Early formulation development, analytical chemistry, bioanalysis, and immunology are just a few of our support services available. Charles River also offers a full range of GLP services for product development from preclinical to clinical and on to market.

Formulation Development & Analytical Chemistry

Knowing the physicochemical characteristics of a drug and having experience with a wide variety of dosing vehicles is vital to successfully formulating a compound for in vivo administration. Charles River offers preformulation screens and analytical chemistry services for a single test article or an analog series to better understand your formulation options early in discovery and reduce delays arising from formulation issues later in development.

 
 
vials 
 
 
 

Our experience covers a vast array of formulation types, including oral, parenteral, creams, ointments, and inhalation products such as nebulizer solutions and powder blends.

Formulation assessments: 

  • pH solubility
  • pH partitioning
  • Excipient compatibility
  • Dosability and suitability
  • Container compatibility
  • Microscopic behavior
  • Bioavailability enhancement
  • Analytical chemistry

 

For future development of your lead compound or compounds, test articles can be stored; formulated; and their concentration, purity, and stability verified to support your GLP preclinical and clinical formulation requirements.

Bioanalysis

The speed of lead candidate selection studies requires an equally rapid analytical tool to efficiently measure drug concentrations in the biological samples collected. Charles River offers non-GLP discovery bioanalytical services either in support of studies conducted in-house or as a stand-alone service with the flexibility and speed to meet the timelines and diverse needs for discovering the best drug candidate.

Our research-grade assay approach via LC-MS/MS can quickly analyze samples for compound ranking. Once a lead candidate has been selected in the discovery analytical process, these methods can be transferred to method development for GLP bioanalytical testing including feasibility, validation, and preclinical and clinical sample analysis.

   
Discover the full range of Charles River Products and Services

For more information please call:

1.877.CRIVER.1 (1.877.274.8371)
askcharlesriver@crl.com

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Charles River Laboratories, Inc.