Even after researchers have identified an active molecule against a disease target, many drugs fail to reach market because of unacceptable toxicity. Our lead optimization toxicology services can uncover possible safety concerns earlier in the drug development process, enabling you to bring forward drug candidates that are more likely to succeed in preclinical testing.
Lead optimization toxicology study designs are customized according to the compound class, therapeutic target, and the testing model of your discovery program. From modular protocols, dosing of rodent and nonrodent species, to analytical chemistry and pathology support, Charles River offers quick study initiation, conduct, and reporting of toxicity when you need it.
Once the late-stage discovery evaluations are complete, Charles River provides a full range of preclinical GLP toxicology, pathology, and laboratory services to help accelerate your lead candidate into the clinic.
- Multilevel customized study designs
- Rodent and nonrodent species
- Variety of dose routes
- Analytical and clinical chemistry
- Pathology
- Toxicokinetics
- Preformatted reports