With each dollar being scrutinized more closely than ever, effective lead candidate screening continues to be an integral part of strategic drug development. Charles River offers fresh and cryopreserved mouse and rat hepatocytes for both suspension and plated applications to optimize your preclinical resources through early compound differentiation.
We provide large lot sizes that allow you to conduct multiple toxicity and metabolism experiments from the same donor pool. Each lot of cells is verified to be metabolically active by ECOD testing and is delivered with clear thawing and handling instructions and a statement of viability. These hepatocytes can be used in a wide range of in vitro applications, including:
- Bioavailability
- Drug-drug interaction assays
- Drug transporter inhibition
- Hepatotoxicity
- Metabolic profiling and stability
- Species-specific dosing
Cryopreserved Hepatocytes
Our cryopreserved mouse hepatocytes are isolated from male CD-1 mice, and our cryopreserved rat hepatocytes are isolated from male Sprague Dawley® rats. All animals have been fully tested and housed in our AAALAC-accredited facility. Animal health reports are available upon request.
Fresh Hepatocytes
For ease-of-use and reliability, we offer fresh rat and mouse hepatocytes in suspension. These cells are isolated and shipped the same day.
Custom Hepatocytes
In addition to our standard products, we offer custom isolations.
- Extensive list of murine strains (male and female)
- Hepatocytes from a client's knockout strain
- Isolation after in vivo dosing with a client's investigational agent
- Additional species available upon request
Ordering
To order hepatocytes, select the appropriate option below.
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Note: These products are for research use only and are not approved or endorsed for human or veterinary use, for application to humans or animals, or for use in in vitro diagnostic or clinical procedures.