Radiolabeled molecules used for PK/biodistribution studies and autoradiography in mice or rats include:
- Commercial pre-labeled (3H,14C) or in-house labeled molecules, particle or cells (125I, 123 I, 99Tc, 111In etc.)
- Gamma and beta counting
- Autoradiography
- SPECT/CT
Click here to view a diagram of an example experimental setting.
125I-Labeled Peptide in Brain (PK)

% of Injected 125I-Labeled Peptide in Plasma

AUC - Plasma

T1/2 - Plasma
125I-Labeled Peptide in Brain (PK)

% of Injected 125I-Labeled Peptide in Brain

AUC - Brain

T1/2 – Brain
125I- Autoradiography Tissue Section+ 125I- Autoradiography Brain Atlas
(overlap) (Paxinos)
