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Radiochemistry 

Radiolabeled molecules used for PK/biodistribution studies and autoradiography in mice or rats include:
  • Commercial pre-labeled (3H,14C) or in-house labeled molecules, particle or cells (125I, 123 I, 99Tc, 111In etc.)
  • Gamma and beta counting
  • Autoradiography
  • SPECT/CT


Click here to view a diagram of an example experimental setting.

125I-Labeled Peptide in Brain (PK)

% of Injected 125I-Labeled Peptide in Plasma


% of Injected 125I-Labeled Peptide in Plasma

 

 


AUC - Plasma

 

 


T1/2 - Plasma

 


125
I-Labeled Peptide in Brain (PK)

 

% of Injected 125I-Labeled Peptide in Brain

 

 

AUC - Brain

 

 

  T1/2 – Brain

 

 

125I- Autoradiography     Tissue Section+ 125I- Autoradiography     Brain Atlas
                                                                 (overlap)                                      (Paxinos)

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