accelerated backcrossing


 
 

MAX-BAXSM (Marker-Assisted Accelerated Backcrossing) is a speed congenics program that facilitates the rapid production of congenic strains of knockout or transgenic animals through the use of microsatellite analysis. This pioneering process selects individuals with preferred genetic backgrounds and greatly reduces the number of generations needed to produce a congenic research model. Backcrossing guided by our microsatellite analysis data achieves 99.9% congenicity in approximately five generations, potentially saving you up to 1.5 years of breeding time (five generations) over conventional backcrossing. We offer about two dozen panels for a variety of the most popular inbred strain comparisons and develop new panels on demand at no charge.

The MAX-BAXSM program is available to you either as a stand-alone service or in conjunction with our in-house breeding services. When performed as a stand-alone service, you can submit a small tissue sample (typically ear or tail) or purified DNA to our facility, after which we will perform the microsatellite analysis and return the data to you with recommendations on which animals to breed in the next generation.

 
 
 
 
 
 

We recommend reading our breeding guidelines for more information. When performed in conjunction with our breeding services, each client is assigned a dedicated project manager who will direct all aspects of the breeding and genotyping. As a fully managed program, all you need to do is submit animals for MAX-BAXSM and we will return fully congenic animals in approximately 15 months.

   

For more information please call:

1.877.CRIVER1
askcharlesriver@crl.com

view all
Detailed information about how our speed congenics program works.
When you're ready to start a project, complete this form and email it to gems@crl.com.
Want to find out how much your project will cost? Fill out a quote request form and one of our project specialists will be in touch with you shortly.

News & Events

view all
Dec 01 Charles River Releases 2009 Resear...
Jul 29 Charles River Supports the Nationa...
Jan 27-Jan 28 Hamamatsu, Japan 25th Annual Meeting of the Japanese Society of Toxic...
Jan 11-Jan 16 San Diego, CA CHI's 8th Annual PepTalk Conference & Exhibition