The mouse embryo assay (MEA) is currently the most widely used bioassay to test for toxicity and functionality of media and materials. Our GEMS group utilizes fresh one- and two-cell embryos produced from a cross between B6D2F1 and B6C3F1 mice to perform this service. The embryos are collected and incubated in the test media or material for a predetermined amount of time. After exposure, the embryos are then cultured for approximately 72-96 hours in a defined culture media and scored for blastocyst development. Charles River requires an 80% development rate from its control and test article to be considered a passing score. If the development is below this required rate, a repeat test is performed at no additional charge. We will work in partnership with you to design a specific MEA to meet your needs. Our laboratory can perform these assays seven days a week under GLP conditions, enabling a quick turnaround time. As with all of our services, our MEA testing is supported by a vast network of PhD-level scientists to ensure accurate, high-quality results.
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