Our teams of experienced and carefully trained technicians can provide necropsy and histopathology services at your facility. Members of these teams are trained in all aspects of necropsy procedures, including special tissue harvest associated with biomedical devices (stents, implants, etc.), and the use of whole-body or organ perfusion technology routinely used in conjunction with neurotoxicolgic protocols or studies having ultrastructural requirements.
- Traveling necropsy team providing support and training
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Necropsy supervision from board-certified pathologists
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In-depth understanding of industry GLP, regulatory guidelines and specifications
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Specialized tissue collection, including whole-body or organ perfusion
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Freezing of tissues for genomic or proteomic analysis and immunohistochemistry
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Aseptic tissue collection techniques for PCR analysis
Each of our laboratories is designed to provide a high-production environment with emphasis on tissue accountability during every step of tissue processing and preparation. All aspects of histology are monitored by laboratory managers, supervisors, and section leaders, ensuring that SOPs are maintained and that work is performed according to specific study protocols.
All activities are also monitored via critical-phase inspections by members of Charles River’s Quality Assurance Unit, operating independently of all project activities, to assure compliance with GLP requirements.
In addition to standard hematoxylin and eosin (H&E) histology, we perform a wide variety of special stains, including enzyme histochemistry. Stains are available for localization of carbohydrates, nucleic acids, polysaccharides, proteins, lipids, enzymes and cellular structures. A full battery of special stains is offered, including immunohistochemistry and RNase-free slides for in situ hybridization.
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Standard hematoxylin and eosin (H&E) staining
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Specialized histochemical stains for specific cellular components
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Plastic processing (GMA) for producing thin sections in support of reproductive pathology and neuropathology
- Plastic embedding (MMA) for microtomy of hard tissues and devices
For more information about our On-site Necropsy and Histopathology Support Services, contact us at 1.877.CRIVER.1 or askcharlesriver@crl.com.