Charles River offers a comprehensive and integrated service for the isolation, analysis, and identification of metabolites in biological matrices in support of drug safety studies. This service can be provided as part of a full ADME package or as a stand-alone study.
Capabilities
- Normal phase, reverse phase, chiral, ion exchange HPLC (with UV, fluorescence, and radiodetection), and thin-layer chromatography with phosphor imaging for metabolite profiling and isolation
- Q-Trap MS for MSn
- QSTAR and Micromass QTOF MS for definitive metabolite identification by accurate mass measurement, plus MetaboLynx™ Application Manager to aid data interpretation
- Synthetic chemistry for synthesis of metabolites, reference standards and internal standards, iodine labeling of proteins, and re-purification of radiochemicals
- Data interpretation by experienced biotransformation scientists in conjunction with client
- Advice on radiosynthesis
- Access to NMR – 1D, 1H, 13C, 19F, 31P (up to 800MHz)
- Access to NMR – 2D COSY, NOESY, 13C-1H correlation
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Biotransformation, metabolite identification, metabolite isolation, drug safety studies, metabolite profiling
biotransformation - Charles River