Charles River Central Laboratory staff support every phase of preclinical and clinical development, conducting all studies according to GLP/GCP standards. In addition to participating in external quality control programs, our laboratories have established strict internal quality guidelines. A CFR Part 11 compliant Laboratory Management Information System (LIMS) ensures control of all aspects of analytical and reporting procedures.
Analytical Services
- Clinical chemistry, hematology, urinalysis, and coagulation studies
- Immunology – automated and standard ELISA, RIA, and chemiluminescence
- Flow cytometry and Q-PCR
- Microbiology and virology
- Genetic analysis, including pharmacogenomics
- Method development and validation services
- Drugs of abuse screening
- Haemocompatibility studies
Preclinical Services
The Central Laboratory has extensive expertise in the use of clinical pathology techniques in laboratory, domestic, and farm animals. This includes safety analysis and pharmacodynamic biomarkers to investigate the efficacy of novel compounds. We support study directors by providing advice on sampling procedures and test selection as well as interpretation of laboratory findings.
Clinical Trial Management Services
- Dedicated project coordinator
- Tailored preparation of laboratory kits, including shipping containers, sample storage tubes, labels, and related shipping documents
- Validated LIMS system for electronic logging and tracking of samples, scheduling laboratory activities, and flexible reporting procedures
- Rapid data access by fax, e-mail, and eTransmit Web™
- Expert scientific advice and medical consultancy
Our services include safety screening of volunteers and patients prior to study and monitoring safety and efficacy during the study using biomarkers. Extensive use of automated systems allow for rapid turnaround of data, enabling clinicians to make prompt judgment on the safety of treatments.